Long non-coding RNAs in Brain-Heart Axis

This project aims to evaluate long non-coding RNAs as key actors in heart and brain diseases.

Objectives

In this study we are primarily interested in studying lncRNAs candidate that have been shown to play a role in heart failure and Parkinson’s disease. Numerous studies have illustrated a strong link between the heart and the brain during the course of the pathology. This link is called Brain-Heart Axis.

Indeed, over the last few decades, the role of non-coding RNAs and their mechanisms within the cells have been increasingly better understood. In this project, our research focuses on the identification and role of non-coding RNAs, longer than 200bp called long non coding RNAs (lncRNAs), as actors in various disease states. Previous work in our laboratory has highlighted that RNA molecules, such lncRNAs, can be valuable tools for clinicians through their actions as potential biomarkers and therapeutic targets.

This study is the main PhD topic of Mrs Shubhra Acharya.

Funding

This project is funded by the Ministry of Higher Education and Research of Luxembourg

 

For more info

• Yvan Devaux, PhD - CVRU Group Leader

• Andrew Lumley, Research Engineer

• Shubhra Acharya, PhD Student